Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third Latin vackra kvinnor method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>

Physiological needs and you can pharmacology regarding curcumin

Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the biggest component of brand new purple dye of turmeric, a keen Indian liven that is taken from this new rhizome of one’s exotic plant Curcuma longa, which is one of the Zingiberaceae household members. In this chapter, i talk about the pharmacological circumstances out-of curcumin and you may speak about the latest unit basics for those circumstances. We upcoming review the latest proven and you may prospective logical uses out of curcumin. Curcumin is well known over the years because the a therapeutic representative, however, the system of action is outlined. The newest pharmacological effects of curcumin seem to be the result of an excellent synergism from networks away from poor biochemical relations that have several physiological aim for the interrelated signaling routes. These types of needs include enzymes such as cyclooxygenase, lipoxygenase and you may proteins kinases, and you may transcription circumstances for example NF-?B, STAT and you will Nrf2. Modulation of those particles impacts downstream affectors that make the antiinflammatory, antioxidant, chemopreventive, anticancer, and you will antimicrobial products of curcumin. Such consequences was looked at during the clinical examples away from curcumin to own aches and you may inflammatory ailment, cancer tumors, Alzheimer problem, aerobic diseases, and you can diabetes. The newest products used changeable dosage out of curcuminwith various other wavelengths and you can course, towards the standard end one to highest dosage off curcumin from the level of g must see healing consequences. Read more

Curcumin: Synthesis, Growing Part when you look at the Aches Government and you may Health Effects

Book Chapter Examples of plant-derived pharmaceuticals having end up being the desire out of continuous and you will rapid lookup and you may innovation interest enjoys, to date, been somewhat scarce. Just after a long period, the past two decades was described as a good 100-fold rise in just how many medical articles published a-year you to are from benefit with the accessibility curcumin inside biomedicine. Read more

Structure, synthesis and physiological products regarding curcumin prodrugs

Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has some possible pharmacological outcomes that can keeps therapeutic programs in lot of problem says, as discussed in detail in the earlier chapter. But not, the potential systematic effectiveness from curcumin is bound from the the physicochemical functions from poor liquid solubility and you may instability, hence end up in lowest bioavailability. Prodrugs of curcumin bring a method to upgrade of the biopharmaceutical and you will pharmacokinetic properties, and may also allow it to be exploitation of your own pharmacological results of curcumin. Within this chapter, we first feedback the latest physicochemical and you can pharmacokinetics away from curcumin. I after that identify the appearance of curcumin prodrugs having increased liquid solubility and increased chemical substances balances which are often converted back into free curcumin up on bioactivation inside the vivo. I emphasize current triumph in this field, which have a focus on the construction, synthesis and you will assessment out-of prodrugs according to promoieties along with proteins, fatty acids, nucleic acids, dicarboxylic acids, and you will polymeric materials instance hyaluronic acid and polyethylene glycol. This section gets the cause for optimization of the physicochemical and biopharmaceutical functions therefore the physical issues out of curcumin prodrugs, on purpose using of these curcumin types for the systematic programs. Find out more